Critical Care Reviews Newsletter 446 28th June 2020

The highlights of this week’s edition are the pre-print of the randomised controlled RECOVERY trial, reporting a huge mortality benefit in critically ill COVID-19 patients, & another RCT comparing resident physician ICU shifts of ≤ 16 hours with longer shifts; systematic reviews and meta analyses on physical distancing, face masks, and eye protection to prevent transmission of SARS-CoV-2, & rehabilitation interventions in critically ill patients; and observational studies on ultra-rapid exome sequencing in critically ill infants, & adverse events after transition from ICU to hospital ward. There are also guidelines on venous thromboembolism prophylaxis in trauma patients, & pediatric airway management in COVID-19 patients; narrative reviews on emerging therapies in acute ischemic stroke, & ventilation-induced lung injury; editorials on making the case for clinical trials and against off-label drug use in COVID-19, & editorial evaluation and peer review during a pandemic; and commentaries on the identification of pathophysiological patterns for triage and respiratory support in COVID-19, & COVID-19 and ethnicity: who will research results apply to?.
The full text of the issue is available via this link

Journal of Critical Care Volume 58 August 2020

The latest issue of this journal was published online in June 2020.  The contents include the following articles:  “The chimeric antigen receptor-intensive care unit (CAR-ICU) initiative: Surveying intensive care unit practices in the management of CAR T-cell associated toxicities”,  “Venous blood lactate concentrations in patients with shock: Interesting but not really helpful” and “Ethical content of expert recommendations for end-of-life decision-making in intensive care units: A systematic review”.
The full contents page is available via this link.  Individual articles can be ordered from the Rotherham NHS Foundation Trust Library and Knowledge Service.  Registered members of the library can make article requests online via this link.
The full text of articles from issues older than one year ago is available via this link to an archive of issues of Journal of Critical Care.  A Rotherham NHS Athens password is required.  Eligible staff can register for an Athens password via this link.  Please speak to the library staff for more details.

Critical Care Reviews Newsletter 445 21st June 2020

The Critical Care Reviews Newsletter, provides you with the best critical care research and open access articles from across the medical literature.
The highlights of this week’s edition are a randomised controlled trial investigating a high-dose 24-h infusion of tranexamic acid in patients with acute gastrointestinal bleeding; systematic reviews and meta analyses on the incidence of acute kidney injury in COVID-19 infection & clinical outcomes of piperacillin-tazobactam administration and dosage strategies in critically ill adults; and observational studies on prone positioning in awake, nonintubated patients with covid-19 hypoxemic respiratory failure & the genetics of severe Covid-19 with respiratory failure. There is also a guideline on reporting randomised trials that use an adaptive design; narrative reviews on neuromuscular blockade management in the critically Ill patient & hyponatremia in the neurologically ill patient; an editorial on endothelial cell dysfunction in SARS-CoV-2 infection; as well as commentaries on delivering evidence-based critical care for mechanically ventilated patients with COVID-19 & a visual guide to the SARS-CoV-2 coronavirus.
The full text of the issue is available via this link

Critical Care Reviews Newsletter 444 16th June 2020

The Critical Care Reviews Newsletter, provides you with the best critical care research and open access articles from across the medical literature.
The highlights are randomised controlled trials on a bundle of coated devices to reduce nosocomial infections in the ICU & hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery; systematic reviews and meta analyses on mucoactive agents for acute respiratory failure & oropharyngeal dysphagia; and observational studies on the interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest & pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2.
The full text of the issue is available via this link

Critical Care Reviews Newsletter 443 June 2020

The Critical Care Reviews Newsletter, provides you with the best critical care research and open access articles from across the medical literature.
The highlights of this week’s edition are randomised controlled trials on convalescent plasma therapy for life-threatening COVID-19 & hydroxychloroquine as postexposure prophylaxis for COVID-19; systematic reviews and meta analyses on fluid volumes during the initial management of sepsis & noninvasive oxygenation strategies in adults with acute hypoxemic respiratory failure; observational studies on patterns of use of adjunctive therapies in patients with early moderate to severe ARDS & thrombolytic door-to-needle time in acute ischemic stroke; and multiple COVID-19 trial protocols, including the REALIST-COVID-19 trial.
The full text of the issue is available via this link

Intensive Care Medicine Volume 46 Number 6 June 2020

To view Intensive Care Medicine’s June issue’s contents page follow this link.
Articles published in this issue include: High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study”, COVID-19 pneumonia: different respiratory treatments for different phenotypes? and “No dose” lung ultrasound correlation with “low dose” CT scan for early diagnosis of SARS-CoV-2 pneumonia.
Together with other articles on COVID 19 these are freely available in full text to everyone.
To read the full text of any of these articles via the journal’s homepage requires a personal subscription to “Intensive Care Medicine” though some are available open access.  Individual articles can be ordered from the Rotherham NHS Foundation Trust Library and Knowledge Service.  Registered members of the library can make article requests online via this link.
The full text of articles from issues older than one year ago is available via this link to an archive of issues of Intensive Care Medicine.  A Rotherham NHS Athens password is required.  Eligible staff can register for an Athens password via this link.  Please speak to the library staff for more details.

Personal protective equipment and intensive care unit healthcare worker safety in the COVID-19 era (PPE-SAFE): An international survey

This article was first published online in the Journal of Critical during June 2020.
Purpose:  To survey healthcare workers (HCW) on availability and use of personal protective equipment (PPE) caring for COVID-19 patients in the intensive care unit (ICU).
Materials and method:  A web-based survey distributed worldwide in April 2020.
Results:  We received 2711 responses from 1797 (67%) physicians, 744 (27%) nurses, and 170 (6%) Allied HCW. For routine care, most (1557, 58%) reportedly used FFP2/N95 masks, waterproof long sleeve gowns (1623; 67%), and face shields/visors (1574; 62%). Powered Air-Purifying Respirators were used routinely and for intubation only by 184 (7%) and 254 (13%) respondents, respectively. Surgical masks were used for routine care by 289 (15%) and 47 (2%) for intubations. At least one piece of standard PPE was unavailable for 1402 (52%), and 817 (30%) reported reusing single-use PPE. PPE was worn for a median of 4 h (IQR 2, 5). Adverse effects of PPE were associated with longer shift durations and included heat (1266, 51%), thirst (1174, 47%), pressure areas (1088, 44%), headaches (696, 28%), Inability to use the bathroom (661, 27%) and extreme exhaustion (492, 20%).
Conclusions:  HCWs reported widespread shortages, frequent reuse of, and adverse effects related to PPE. Urgent action by healthcare administrators, policymakers, governments and industry is warranted.
The full text of the article is available via this link

Critical Care Reviews Newsletter 442 12th June 2020

The Critical Care Reviews Newsletter, provides you with the best critical care research and open access articles from across the medical literature for the week of May 25th to 31st.
The highlights of this edition are randomised controlled trials investigating remdesivir & ruxolitinib in COVID-19; and observational studies on patients undergoing surgery with SARS-CoV-2 infection & the aerosol box for intubation in COVID-19 patients.  There are also guidelines on managing the airway in patients with COVID19  & prone position ventilation in non-intubated, spontaneously ventilating patients; narrative reviews on  neurologic manifestations of coronavirus infections & sepsis-induced cardiac dysfunction; editorials on highflow nasal oxygen in COVID19 & universal airway management; and commentaries on pulmonary hyperinflation in mechanically ventilated critical patients & conducting clinical research during the covid-19 pandemic.
The full text of the issue is available via this link

Critical Care Reviews Newsletter 441 10th June 2020

This Critical Care Reviews Newsletter brings you the best critical care research and open access articles from across the medical literature for the week May 18th to 24th.
“The highlights of this edition are randomised controlled trials investigating remdesivir & ruxolitinib in COVID-19; and observational studies on patients undergoing surgery with SARS-CoV-2 infection & the aerosol box for intubation in COVID-19 patients. There are also guidelines on managing the airway in patients with COVID19 & prone position ventilation in non-intubated, spontaneously ventilating patients; narrative reviews on neurologic manifestations of coronavirus infections & sepsis-induced cardiac dysfunction; editorials on high‐flow nasal oxygen in COVID‐19 & universal airway management; and commentaries on pulmonary hyperinflation in mechanically ventilated critical patients & conducting clinical research during the covid-19 pandemic.”
The full text of the issue is available via this link 

Critical Care Reviews Newsletter 440 9th June 2020

The Critical Care Reviews Newsletter brings you the best critical care research and open access articles from across the medical literature for the week May 18th to 24th.
The highlights of this edition are two COVID-19 randomised controlled trials investigating remdesivir & the triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin; systematic reviews and meta analyses on periprocedural bridging anticoagulation & mortality in sepsis and septic shock in Europe, North America and Australia; and observational studies on the postmortem examination of patients with covid-19, an outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic & the latest publication from the RADAR project, describing the results of a survey on fluid management and deresuscitation practices.
There are guidelines on the treatment of cerebral edema & liver trauma; narrative reviews on acute kidney injury in patients with COVID-19 & non-ST-elevation myocardial infarction; editorials on renal replacement therapy initiation & unconventional approaches to mechanical ventilation; commentaries on accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) & universal masking in hospitals in the Covid-19 era.
The full text of the issue is available via this link