The 305th Critical Care Reviews Newsletter brings “you the best critical care research and open access articles from across the medical literature over the past seven days”. The highlights of this week’s newsletter are randomised controlled trials on tapered-cuff tracheal tubes for the prevention of micro-aspiration and red cell transfusion triggers in cardiac surgery. There is also the protocol of the COAST trial, comparing high flow versus oxygen versus control in African children with severe pneumonia. Narrative reviews include ones on brain monitoring in adult and paediatric ECMO patients, cardiogenic shock, intraoperative mechanical ventilation and interhospital transfer of critically ill patients. There are editorials on fixed minimum volume sepsis resuscitation (pro & con) and when antibiotic treatment fails.