Critical Care Reviews Newsletter 445 21st June 2020

The Critical Care Reviews Newsletter, provides you with the best critical care research and open access articles from across the medical literature.
The highlights of this week’s edition are a randomised controlled trial investigating a high-dose 24-h infusion of tranexamic acid in patients with acute gastrointestinal bleeding; systematic reviews and meta analyses on the incidence of acute kidney injury in COVID-19 infection & clinical outcomes of piperacillin-tazobactam administration and dosage strategies in critically ill adults; and observational studies on prone positioning in awake, nonintubated patients with covid-19 hypoxemic respiratory failure & the genetics of severe Covid-19 with respiratory failure. There is also a guideline on reporting randomised trials that use an adaptive design; narrative reviews on neuromuscular blockade management in the critically Ill patient & hyponatremia in the neurologically ill patient; an editorial on endothelial cell dysfunction in SARS-CoV-2 infection; as well as commentaries on delivering evidence-based critical care for mechanically ventilated patients with COVID-19 & a visual guide to the SARS-CoV-2 coronavirus.
The full text of the issue is available via this link

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