TroponinI at admission in the intensive care unit predicts the need of dialysis in septic patients

This article by de Almeida Thiengo and colleagues was published in BMC Nephrology in November 2018.
Background:  In a previous study we showed that troponin I (TnI) > 0.42 ng/mL predicted the need of dialysis in a group of 29 septic patients admitted to the intensive care unit (ICU). We aimed to confirm such finding in a larger independent sample.
Methods:  All septic patients admitted to an ICU from March 2016 to February 2017 were included if age between 18 and 90 years, onset of sepsis  0.42 ng/mL. These patients had serum creatinine slightly higher (1.66 ± 0.34 vs. 1.32 ± 0.39 mg/dL; P <  0.0001)than those with lower TnI and similar urine output (1490 ± 682 vs. 1406 ± 631 mL;P = 0.44). At the end of the follow-up period, 70.0% of the patients with lower TnI were alive in comparison with 38.6% of those with higher TnI (p = 0.0014).After 30 days, 69.3 and 2.9% of the patients with lower and higher TnI levels remained free of dialysis, respectively (p  0.42 ng/mL persisted as a strong predictor of dialysis need (hazard ratio 3.48 [95%CI 1.69-7.18]).
Conclusions:  TnI levels at ICU admission are a strong independent predictor of dialysis need in sepsis.
The full text of the article is freely available via this link.

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