Interventions affecting mortality in critically ill and perioperative patients

Martina, B.R. et al. Journal of Critical Care | Published online: 4 May 2017

Highlights: 

  • No systematic exploration of confounders in randomized controlled trials reporting a significant effect on mortality in critically ill patients has been performed.
  • Almost half of these trials were single centre and one third were not analysed according to the intention to treat principle, inflating effect size.
  • Blinded and/or multicentre design was associated with an increased number needed to treat/harm.
  • Major systematic biases exist and affect trial findings irrespective of the intervention being studied.

Read the full abstract here

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