Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study

John P Donnelly, MSPHa, b, Prof Monika M Safford, MDd, e, Nathan I Shapiro, MDf, g, Prof John W Baddley, MDc, Prof Henry E Wang, MD. Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study. The Lancet Infectious Diseases.  Online First 3 March 2017.

Study (n=30239) of 3 scores [infection and systemic inflammatory response syndrome (SIRS), elevated sepsis-related organ failure assessment (SOFA), elevated quick SOFA (qSOFA)].  SIRS, SOFA, and qSOFA classifications identified different incidences and mortality. Our findings support the use of the SOFA and qSOFA classifications to identify patients with infection who are at elevated risk of poor outcomes. These classifications could be used in future epidemiological assessments and studies of patients with infection.

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