Acute liver failure: an up-to-date approach

Cardoso, F.P. et al. Journla of Critical Care. Published online: 19 January 2017
Image source: Spike Walker – Wellcome Images // CC BY-NC-ND 4.0

Image shows light microscopy of liver blood vessels


  • Outcomes of patients with acute liver failure have been improving, but morbidity and mortality are still of concern.
  • Earlier recognition and referral to the intensive care unit have been important to improve these patients’ outcomes.
  • Intensive care management should take into consideration hepatic encephalopathy, cerebral edema and intracranial hypertension, hemodynamics, acute kidney injury, coagulopathy, and infection.
  • Selection of patients for liver transplantation has been based on prognostic scores (e.g. Kings’ College criteria) but limitations may apply.

Read the full abstract here


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