This trial is reported in the latest issue of the Journal of Clinical and Translational Endocrinology (Volume 4, June 2016). It is the first double blind RCT of vitamin D therapy in mechanically ventilated patients. It demonstrated that treatment with placebo, 250,000 IU or 500,000 IU enteral vitamin D3 was well tolerated. Results showed a significant increase in plasma 25(OH)D from baseline to day 7, significant decrease in hospital length of stay for vitamin D3 treated subjects and no change in plasma LL-37 according to treatment group.
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