High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial

This trial is reported in the latest issue of the Journal of Clinical and Translational Endocrinology (Volume 4, June 2016).  It is the first double blind RCT of vitamin D therapy in mechanically ventilated patients.  It demonstrated that treatment with placebo, 250,000 IU or 500,000 IU enteral vitamin D3 was well tolerated.  Results showed a significant increase in plasma 25(OH)D from baseline to day 7, significant decrease in hospital length of stay for vitamin D3 treated subjects and no change in plasma LL-37 according to treatment group.

The full text of the article is available freely via this internet link.

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