Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial

The Lancet Infectious Diseases

Median consumption of antibiotics was 7.5 daily defined doses (DDD) in the procalcitonin-guided group v 9.3 DDD in the standard-of-care group (absolute difference 2.69, p<0.0001), and median duration of treatment was 5 v 7 days respectively (absolute difference 1.22, p<0.0001).

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