Sepsis care bundles reduce mortality odds 40%

Compliance with sepsis care bundles can significantly reduce death in hospital. However compliance rates are generally low.

This study assessed how the Surviving Sepsis Campaign was implemented in various countries and the impact of implementing these care bundles for people with severe sepsis or septic shock. Data were analysed about 1,794 patients from 62 countries. Compliance with all the three-hour bundle metrics was 19%. Compliance was associated with lower hospital mortality. Compliance with all the six-hour bundle metrics was 36%. This was associated with lower hospital mortality. Overall, patients who received all aspects of the care bundles had a 40% reduction in the odds of dying in hospital with the three-hour bundle and a 36% reduction with the six-hour bundle.
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